Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998.

نویسندگان

  • A Carattoli
  • F Tosini
  • W P Giles
  • M E Rupp
  • S H Hinrichs
  • F J Angulo
  • T J Barrett
  • P D Fey
چکیده

Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 5  شماره 

صفحات  -

تاریخ انتشار 2002